effect of sumac rhuscoriaria L. powder on serum glycemic status, ApoB, ApoA-I and total antioxidant capacity in type 2 diabetic patients

Sumac Rhuscoriaria L. is used as an herbal remedy in traditional medicine. The aim of this study was to determine the effects of sumac [R. coriaria] on serum glycemic status, apolipoprotein [apo] B, apoA-I and total antioxidant capacity [TAC] in type 2 diabetic patients. This double blind randomized controlled clinical trial was conducted on 41type 2 diabetic volunteers randomly assigned into 3g/day sumac powder [n=22] or placebo [n=19] groups over 3 months. Blood samples were collected before and after the intervention. Serum glucose and HbA1c were measured using enzymatic and turbidimetric inhibition immunoassay methods, respectively. ApoB, apoA-I and TAC were determined using turbidimetric immunoassay and spectrophotometric methods, respectively. There were significant decreases in serum glucose and HbA1c and als oapoB levels at the end of study compared with initial values [P< 0.0001, P= 0.002 and P< 0.0001, respectively]. Also, there was a significant difference in HbA1c and TAC levels between placebo and sumac groups at the end of study [P< 0.05]. In sumac group, there were significant increase in apoA-I and TAC [P< 0.0001] compared with initial values. The mean of differences of serum glucose, HbA1c, apoB, apoA-I, apoB/apoA-I ratio and TAC between groups were significant [P< 0.05]. In conclusion, these results showed the favorite effect of sumac consumption on serum glycemic status, apoB, apoA-I and TAC levels in in type 2 diabetic patients

computational study of cytotoxicity of substituted amides of pyrazine-2-carboxylic acids using QSAR and DFT based molecular surface electrostatic potential

Pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. In this study, B3 p 86 / 6 - 31 + + G was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. Several statistical properties including potentials extrema [V[s'mm]>V[s'max], the average of positive electrostatic potential on the surface [V[s+], the average of V[r] over the surface [Vs] and the Lowest Unoccupied Molecular Orbital [LUMO] and system cytotoxicities were computed. Statistically, the most significant correlation is a five -parameter equation with correlation coefficient, R[2] values of 0.922 and R[2adj] = 0.879. The obtained models allowed us to reveal cytotoxic activity of substituted amides of Pyrazine2-carboxcylic acid

effects of berberis vulgaris fruit extract on serum lipoproteins, apob, apoa-i, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patients

Type 2 diabetes is a well-known endocrine and metabolic disorder which has reached epidemic proportions worldwide and represents a serious public health concern. Hyperglycemia and dyslipidemia are two major abnormalities which are major cardiovascular risk factors. Berberine is a major alkaloid in Berberis vulgaris fruit extract [BVFE] which have important role in regulation of serum glucose and fat metabolism in-vivo and in-vitro but its role in type 2 diabetes have not been extensively examined. The aim of this study was the effect of BVFE on serum lipoproteins, apoB, apoA-I, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patients. In a double-blind randomised clinical trial, 31 diabetic patients were randomly assigned to 3 g/d BVFE or placebo for 3 months. Serum glucose, lipoproteins, apoB, apoA-I, insulin, homocysteine and HbA1c were measured at the baseline and also at the end of the 3[rd] month. At the beginning and end of 1[st], 2[nd] and 3[rd] months, a 24-h dietary recall questionnaire about each patients was completed. Data were analyzed by SPSS version 16. There were significant decreases in serum TG, TC, LDL-c, apo B, glucose, and insulin and also a significant increase in TAC at the end of the study in BVFE group compared to the control group [p = 0.001, p = 0.001, p = 0.001, p = 0.001, p = 0.002, p = 0.01 and p = 0.0001 respectively]. There were significant differences in serum TG [p = 0.0001], TC [p = 0.001], LDL-c [p = 0.001], apoB [p = 0.001], glucose [p = 0.002], insulin [p = 0.01], TAC [p = 0.005], and insulin resistance [p = 0.01] between the two groups at the end of the study; but homocysteine, HbA[1c] and HDL-c showed no significant changes between the two groups at the end of study. The intake of 3 g/d BVFE for 3 months may have benefical effects on lipoproteins, apoproteins, glycemic control and TAC in type 2 diabetic patients